Browse Exhibits (1 total)
Jenna McKune | Elevated Plasma Creatinine Levels in Old Female Retinal Dystrophic Pigmented Royal College of Surgeon (RCS) Rats
The Royal College of Surgeons (RCS) pigmented rat is known as being an animal model for studying inherited retinal degeneration seen in humans, and kidney problems are seen with eye problems. There is no information on kidney function in this model, so the purpose of this study was to investigate whether there are also kidney problems in this model. A decrease in glomerular filtration rate (GFR) is seen when there is kidney dysfunction and is usually accompanied by an increase in the plasma creatinine concentration; there was a significant increase in the plasma creatinine concentration in the old female RCS rats compared to their control counterparts, indicating they have kidney issues in combination with their eyes.
Faculty Mentor: Dr. Marianna Zamlauski-Tucker
Department of Biology
Undergraduate